Our research in the field of psychiatry and psychotherapy is guided by the conception of mental disorders as biopsychosocial disorders. As part of this interest, the group is actively involved in the Düsseldorf DFG Collaborative Research Centre 991 “The Structure of Representations in Language, Cognition, and Science” with a research project on the application of frame theory to the conception of mental disorders. Another research focus is the classification of mental disorders, especially psychotic disorders, and there is an active participation in both the development processes of DSM-5 (American Psychiatric Association) and ICD-11 (World Health Organisation). As regards the biological foundations of mental disorders, investigations deal with the roles of genetics, protein biochemistry, and disturbed neurocircuits (using EEG and MRT) in the pathophysiology of mental disorders. In the psychological field, the focus is on developing psychotherapeutic interventions especially in schizophrenia. In the field of social causes of mental disorders, the main research interest is the stigmatization of people with mental disorders and ways how to reduce this stigmatization (research project for the World Psychiatric Association). Furthermore, our research groups participate in multicenter clinical trials to improve the pharmacological treatment of mental disorders including the improved recognition and treatment of early stages of severe mental disorders like schizophrenia. Another major aspect is healthcare research in the field of mental disorders, with research projects being coordinated for the Federal Medical Chamber (Mental healthcare utilization in Germany) and the German Society for Psychiatry (development of quality indicators for mental healthcare, development of the updated S3 Guideline “Schizophrenia”).